Molecular Info® Copy Right © 2001
Institute of Molecular Development LLC
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Neonatal sunburn and melanoma in mice
FRANCES P. NOONAN, JUAN A. RECIO, HISASHI TAKAYAMA, PAUL DURAY, MIRIAM R. ANVER, WALTER L. RUSH, EDWARD C. DE FABO and GLENN MERLINO
The Nature
, September 2001, 413: 271 - 272.
Retrospective epidemiological data have indicated that cutaneous malignant
melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet
radiation, particularly in children. A genetically engineered mouse model shows that a single
dose of burning ultraviolet radiation to neonates, but not adults, is necessary and sufficient
to induce tumours with high penetrance which are reminiscent of human
melanoma. Childhood sunburn may pose a significant risk of developing this cutaneous malignant
melanoma.
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