Molecular
Info® Copy Right © 2001
Institute of Molecular Development LLC
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A genome-wide scan for linkage to human
exceptional longevity identifies a locus on chromosome 4
Annibale A. Puca, Mark J. Daly, Stephanie J. Brewster, Tara C. Matise, Jeffrey Barrett, Maureen Shea-Drinkwater, Sammy Kang, Erin Joyce,
Julie Nicoli, Erica Benson, Louis M. Kunkel, and Thomas Perls
The PNAS
, August 2001, 98(18): 10505-10508.
Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. A genome-wide scan for such predisposing loci was conducted by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity. By using nonparametric analysis, significant evidence for linkage was noted for chromosome 4 at D4S1564 with a MLS of 3.65 (P = 0.044). The analysis was corroborated by a parametric analysis (P = 0.052). These linkage results indicate the likelihood that there exists a gene, or genes, that exerts a substantial influence on the ability to achieve exceptional old age.
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Molecular
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