Molecular
Info® Copy Right © 2001
Institute of Molecular Development LLC
|
|
Translating the Histone Code
Thomas Jenuwein, C. David Allis
The Science, August 2001,
293: 1070 - 1074.
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino termini,
thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications
can generate synergistic or antagonistic interaction affinities for chromatin-associated
proteins, which in turn dictate dynamic transitions between transcriptionally active or
transcriptionally silent chromatin states. The combinatorial nature of histone amino-terminal
modifications thus reveals a "histone code" that considerably extends the information potential
of the genetic code.
|
|
|
Molecular
Info® 
