Molecular
Info® Copy Right © 2001
Institute of Molecular Development LLC
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Epigenetic Aspects of X-Chromosome Dosage Compensation
Yongkyu Park, Mitzi I. Kuroda
The Science, August 2001,
293: 1083 - 1086.
The X chromosomes of mammals and fruit flies exhibit unusual properties that have evolved to
deal with the different dosages of X-linked genes in males (XY) and females (XX). The X
chromosome dosage-compensation mechanisms discovered in these species are evolutionarily
unrelated, but exhibit surprising parallels in their regulatory strategies. These features
include the importance of noncoding RNAs, and epigenetic spreading of chromatin-modifying
activities.
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