Molecular Info®

Molecular Info® Copy Right © 2001 Institute of Molecular Development LLC

Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells Jeong-Soo Park, Woong-Yang Park, Kyoung-A Cho, Deok-In Kim, Byung-Hak Jhun, Seung-Ryul Kim, and Sang Chul Park The FASEB Journal, May 9, 2001 A significant decrease of amphiphysin-1 is strongly related to the reduction of receptor-mediated endocytosis in both human diploid fibroblasts of multipassages and hydrogen peroxide-induced premature senescence. Microinjection of wild-type amphiphysin-1 into senescent cells restores the ability of the transferrin uptake nearly up to that of the presenescent cell. The loss of endocytotic activity of senescent cells is directly related to the down-regulation of amphiphysin-1, and its functional restorability can be induced by simple microinjection of amphiphysin-1 gene in the senescent cells.