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Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics
Simon Mead, Michael P. H. Stumpf, Jerome Whitfield, Jonathan A. Beck, Mark Poulter, Tracy Campbell, James Uphill, David Goldstein, Michael Alpers, Elizabeth M. C. Fisher, John Collinge
The Science, April 2003, 299, .
In the Fore linguistic group of the Papua New Guinea, an acquired prion disease, Kuru, is suppresed by heterozygosity for a common polymorphism in the human prion protein gene (PRNP), which confers relative resistance to prion diseases. This PRNP haplotype diversity is widely found in modern humans.
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