Molecular Info® Copy Right © 2001
Institute of Molecular Development LLC
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Identification of novel genes coding for small expressed RNAs
Mariana Lagos-Quintana, Reinhard Rauhut, Winfried Lendeckel, and Thomas Tuschl
The Science, October 2001, 294: 853-858.
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Nelson C. Lau, Lee P. Lim, Earl G. Weinstein, and David P. Bartel
The Science, October 2001, 294: 858-862.
An Extensive Class of Small RNAs in Caenorhabditis elegans
Rosalind C. Lee and Victor Ambros
The Science, October 2001, 294: 862-864.
A large class of small temporal RNAs(stRNAs), microRNAs (miRNAs), or small RNAs are identified in Caenorhabditis elegans. Among them, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing.
The abundance of these small RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, small RNAs have broad regulatory functions in animals.
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