Molecular Info® Copy Right © 2001
Institute of Molecular Development LLC
|
|
Complete genome sequence of Salmonella enterica
serovar Typhimurium LT2
MICHAEL MCCLELLAND, KENNETH E. SANDERSON†, JOHN SPIETH, SANDRA W. CLIFTON, PHIL LATREILLE, LAURA COURTNEY, STEFFEN PORWOLLIK, JOHAR ALI, MIKE DANTE, FEIYU DU, SHUNFANG HOU, DAN LAYMAN, SHAWN LEONARD, CHRISTINE NGUYEN,
KELSI SCOTT, ANDREA HOLMES, NEENU GREWAL, ELIZABETH MULVANEY,
ELLEN RYAN, HUI SUN, LILIANA FLOREA, WEBB MILLER, TAMBERLYN STONEKING,
MICHAEL NHAN, ROBERT WATERSTON & RICHARD K. WILSON
The Nature, October 2001, 413: 852 - 856.
Salmonella enterica subspecies I, serovar Typhimurium is a leading
cause of human gastroenteritis.
The
4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain
LT2 were sequenced. The distribution of close homologues of S. typhimurium LT2 genes in eight related
enterobacteria was determined using previously completed genomes of three related
bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and
Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray
of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S.
typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29%
missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2
confined to subspecies I of S. enterica-containing most mammalian and bird
pathogens-are useful for studies of epidemiology, host specificity and pathogenesis.
|
|
|
Molecular Info® 
